NF2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NF2 wild type allele is located in the vicinity of 22q12.2 and is approximately 95 kb in length. This allele, which encodes merlin protein, plays a role in the mediation of protein localization, cytoskeletal conformation and ion transport. Mutations in this allele are a factor in the occurrence of neurofibromatosis type II, schwannomatosis and somatic meningioma.

**Synonyms:** - ACN - BANF - Neurofibromin 2 (Bilateral Acoustic Neuroma) Gene - Neurofibromin 2 (Merlin) Gene - Neurofibromin 2 wt Allele - SCH