TLX1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TLX1 wild-type allele is located in the vicinity of 10q24 and is approximately 7 kb in length. This allele, which encodes T-cell leukemia homeobox protein 1, plays roles in the regulation of RNA polymerase II-mediated transcription and in the development of the spleen. T-cell acute lymphoblastic leukemia is linked to both t(10,14)(q24;q11) and t(7,10)(q35;q24) translocations, resulting in fusion of this gene to either the T-cell receptor delta or beta locus.

**Synonyms:** - HOX11 - Homeo Box 11 (T-Cell Lymphoma 3-Associated Breakpoint) Gene - Homeo Box-11 (T-Cell Leukemia-3 Associated Breakpoint, Homologous To Drosophila Notch) Gene - Homeobox 11 Gene - T Cell Leukemia Homeobox 1 wt Allele - T-Cell Leukemia Homeobox 1 Gene - T-Cell Leukemia, Homeobox 1 wt Allele - T-Cell Lymphoma 3-Associated Breakpoint Gene - TCL3 - TCL3 Gene - TLX1