AFF3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human AFF3 wild-type allele is located within 2q11.2-q12 and is approximately 595 kb in length. This allele, which encodes AF4/FRM2 family member 3 protein, may play roles in both the activation of RNA polymerase II-directed transcription and the development of lymphoid tissues. Acute lymphoblastic leukemia is associated with rearrangement and fusion of this gene to the MLL gene.

**Synonyms:** - AF4/FMR2 Family, Member 3 wt Allele - LAF4 - LAF4 Gene - Lymphoid Nuclear Protein Related to AF4 Gene