AFF1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human AFF1 wild-type allele is located in the vicinity of 4q21 and is approximately 206 kb in length. This allele, which encodes AF4/FMR2 family member 1 protein, is involved in the modulation of transcription by RNA polymerase II. Several acute leukemias are associated with the translocation t(4;11)(q21;q23) of the gene and the MLL gene.

**Synonyms:** - AF-4 - AF4 - AF4-MLL - AF4/FMR2 Family Member 1 wt Allele - AF4/FMR2 Family, Member 1 Gene - MGC134969 - MLL/AF4 - MLLT2 - Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 2 Gene - PBM1