FOXO4 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human FOXO4 wild-type allele is located in the vicinity of Xq13.1 and is approximately 7 kb in length. This allele, which encodes forkhead box protein O4, plays a role in the modulation of transcription by RNA polymerase II. Acute nonlymphocytic leukemias and T-cell acute lymphocytic leukemias are associated with translocations t(X;11)(q13;q23) of the gene to the MLL gene.

**Synonyms:** - AFX - AFX1 - ALL1-Fused Gene from X Chromosome - Forkhead Box O4 wt Allele - MGC120490 - MLLT7 - Mixed Lineage Leukemia, Translocated to, 7 Gene - Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated to, 7 Gene - Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 7 Gene