NFKB2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NFKB2 wild-type allele is located in the vicinity of 10q24 and is approximately 8 kb in length. This allele, which encodes nuclear factor NF-kappa-B p100 subunit protein, is involved in the modulation of transcription by RNA polymerase II. A variety of leukemias and lymphomas are associated with translocations t(10;14)(q24;q11) of the gene and the T-cell receptor alpha or delta locus, or t(10;14)(q24;q32) of this gene and the IGHA1 locus.

**Synonyms:** - CVID10 - H2TF1 - LYT-10 - LYT10 - NF-kB2 - Nuclear Factor Kappa B Subunit 2 wt Allele - Nuclear Factor of Kappa Light Chain Gene Enhancer in B-cells 2 Gene - Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells 2 (p49/p100) Gene - p100 - p49/p100 - p52