THRB wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human THRB wild-type allele is located in the vicinity of 3p24.2 and is approximately 377 kb in length. This allele, which encodes thyroid hormone receptor beta-1 protein, plays a role in the progression of the thyroid hormone signaling pathway. Mutations in the gene, which occur in the hormone-binding region, are associated with generalized resistance to thyroid hormone.

**Synonyms:** - ERBA2 - THR1 - THRB1 - THRB2 - Thyroid Hormone Receptor Beta Gene - Thyroid Hormone Receptor, Beta (Erythroblastic Leukemia Viral (V-ERB-A) Oncogene Homolog 2, Avian) wt Allele