RELA wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human RELA wild-type allele is located in the vicinity of 11q13 and is approximately 9 kb in length. This allele, which encodes transcription factor p65 protein, plays a role in the modulation of transcription by RNA polymerase II. Infrequently, lymphoproliferative disorders are associated with the translocation t(11;14)(q14;q32) of this gene. Amplification or increased expression of this gene has also been noted in some cases of squamous carcinomas of the head and neck and adenocarcinomas of the breast and stomach.

**Synonyms:** - AIF3BL3 - CMCU - NFKB, p65 Subunit Gene - NFKB3 - Nuclear Factor Kappa-B, Subunit 3 Gene - RELA - RELA Proto-Oncogene, NF-KB Subunit wt Allele - RELA Protooncogene, NFKB Subunit Gene - p65 - v-REL Avian Reticuloendotheliosis Viral Oncogene Homolog A Gene - v-REL Reticuloendotheliosis Viral Oncogene Homolog A, Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells 3, p65 (Avian) Gene - v-Rel Reticuloendotheliosis Viral Oncogene Homolog A Gene