Dacomitinib

**Semantic type:** Pharmacologic Substance

**Definition:** A highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors.

**Synonyms:** - (2E)-N-(4-((3-Chloro-4-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-yl)-4-Piperidin-1-ylbut-2-Enamide - DACOMITINIB - EGFR Inhibitor PF-00299804 - PF 00299804 - PF-00299804 - PF-00299804 - PF-00299804-03 - PF-299804 - PF00299804 - Vizimpro