Iodine I-124 Girentuximab

**Semantic type:** Amino Acid, Peptide, or Protein|Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** A radioimmunoconjugate comprised of the chimeric monoclonal antibody G250 conjugated with the positron emitter iodine I 124. The antibody moiety of iodine I 124 chimeric monoclonal antibody G250 may bind to renal cell carcinoma (RCC) cells that express the RCC-associated antigen G250, allowing detection of tumor-localized iodine I 124 with positron emission tomography (PET). G250 is a cell surface tumor-associated antigen (TAA) that is found in the majority of renal cell carcinomas.

**Synonyms:** - 124I-cG250 - 124IcG250 - GIRENTUXIMAB I-124 - I 124 MoAb cG250 - Iodine (124I) Girentuximab - Iodine I 124 Chimeric Monoclonal Antibody G250 - Redectane