Yttrium Y-90-DOTA-Girentuximab

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A radioimmunoconjugate comprised of the chimeric monoclonal antibody cG250 conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with the beta-emitting radioisotope yttrium 90. The antibody moiety of yttrium 90 DOTA chimeric monoclonal antibody cG250 binds to renal cell carcinoma cells expressing the G250 antigen, thereby selectively delivering a cytotoxic dose of beta radiation.

**Synonyms:** - 90Y-DOTA-cG250 - Yttrium Y 90-DOTA-Chimeric Monoclonal Antibody cG250 - Yttrium-90 DOTA Conjugated Chimeric MoAb G250