Integrin Beta-5

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** Integrin beta-5 (799 aa, ~88 kDa) is encoded by the human ITGB5 gene. This type I membrane protein forms a heterodimer with integrin alpha-V protein. The resulting complex binds to the tripeptide R-G-D, an amino acid sequence present in a number of ligands including vitronectin, fibronectin, fibrinogen, and laminin. Ligand binding regulates cell adhesion, growth and migration.

**Synonyms:** - ITGB5 Protein - Integrin, Beta 5