CDC73 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CDC73 wild-type allele is located in the vicinity of 1q25 and is approximately 132 kb in length. This allele, which encodes parafibromin protein, plays a role in the modulation of both RNA polymerase II-directed transcription and histone methylation. Hyperparathyroidism-jaw tumor syndrome is associated with mutations that result in truncation of this gene.

**Synonyms:** - C1orf28 - Cell Division Cycle 73 wt Allele - Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog (S. cerevisiae) Gene - Cell Division Cycle Protein 73, S. cerevisiae, Homolog of Gene - FIHP - FLJ23316 - Familial Isolated Hyperparathyroidism Gene - HPT-JT - HPTJT - HRPT1 - HRPT2 - HYX - Hyperparathyroidism 1 Gene - Hyperparathyroidism 2 (with Jaw Tumor) Gene - Hyrax, Drosophila, Homolog of Gene - Paf1/RNA Polymerase II Complex Component Gene - Parafibromin Gene