PHLDA2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PHLDA2 wild-type allele is located in the vicinity of 11p15.5 and is approximately 1 kb in length. This allele, which encodes pleckstrin homology-like domain family A member 2 protein, is involved in tumor suppression. Aberrant alterations in this region generate variant alleles that are associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.

**Synonyms:** - BRW1C - BWR1C - Beckwith-Wiedemann Region 1C Gene - HLDA2 - IPL - Pleckstrin Homology-Like Domain, Family A, Member 2 wt Allele - TSSC3 - Tumor Suppressing Subchromosomal Transferable Fragment cDNA 3 - Tumor Suppressing Subtransferable Candidate 3 Gene - Tumor-Suppressing STF cDNA 3 - Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 3