PMEL wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PMEL wild-type allele is located in the vicnity of 12q13.2 and is approximately 19 kb in length. This allele, which encodes melanocyte protein PMEL, is involved in the regulation of melanosome biogenesis. Elevated expression of the gene is observed in some melanomas.

**Synonyms:** - D12S53E - ME20 - ME20-M - ME20M - P1 - PMEL17 - Premelanosome Protein wt Allele - SI - SIL - SILV - Silver (Mouse Homolog) Gene - Silver (Mouse Homolog) Like Gene - Silver Homolog (Mouse) Gene - Silver, Mouse, Homolog of Gene - gp100