Hexestrol

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic hydrogenated derivative of diethylstilbestrol (DES). Hexestrol exhibits strong affinity for estrogen receptors that are overexpressed in some types of cancers. When conjugated with a neoplastic drug, hexestrol may selectively concentrate the cytotoxic agent in estrogen receptor-rich tumors. This agent may also be mutagenic. (NCI04)

**Synonyms:** - (+-)-Hexestrol - (.+-.)-Hexestrol - (R*,S*)-4,4'-(1,2-Diethyl-1,2-ethanediyl)bis[phenol] - (R*,S*)-4,4'-(1,2-Diethyl-1,2-ethanediyl)bis[phenol] - Cycloestrol - Erythrohexestrol - HEXESTROL - Sinestrol