5-Hydroxyeicosatetraenoic Acid

**Semantic type:** Biologically Active Substance|Organic Chemical

**Definition:** A lipoxygenase metabolite of arachidonic acid and an intermediate in the pathway of leukotriene synthesis. 5-hydroxyeicosatetraenoic acid (5-HETE) is also a modulator of tubuloglomerular feedback, one of the mechanism the kidney uses to regulate glomerular filtration rate. Along with leukotriene B4, 5-HETE is often used as biomarker in evaluating eicosanoid metabolism and disease state.

**Synonyms:** - 5-HETE - 5-HETE - 5-Hydroxy-6,8,11,14-eicosatetraenoic Acid - HETE - Hydroxyeicosatetraenoic Acid