Ibuprofen

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)

**Synonyms:** - (.+ -.)-p-Isobutylhydratropic acid - Advil - Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)- - IBUPROFEN - Motrin - Motrin - Motrin - ibuprofen - p-Isobutylhydratropic Acid - p-Isobutylhydratropic acid