Isotretinoin

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.

**Synonyms:** - 13-cRA - 13-cis retinoic acid - 13-cis-Retinoate - 13-cis-Retinoic Acid - 13-cis-Vitamin A Acid - 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid - Absorica - Accure - Accutane - Amnesteem - Cistane - Claravis - ISOTRETINOIN - Isotretinoinum - Isotrex - Isotrexin - Myorisan - Neovitamin A - Neovitamin A Acid - Oratane - Retinoicacid-13-cis - Ro 4-3780 - Ro-4-3780 - Roaccutan - Roaccutane - Roacutan - Sotret - ZENATANE - cis-Retinoic Acid - isotretinoin