Ketoconazole

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)

**Synonyms:** - Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine - Fungarest - Fungoral - KETOCONAZOLE - Ketoderm - Ketoisdin - Nizoral - Orifungal M - Panfungol - R-41400 - Xolegel - ketoconazole