Smoothened Antagonist IPI-609

**Semantic type:** Pharmacologic Substance

**Definition:** A semi-synthetic cyclopamine analogue and an inhibitor of SMO and the Hedgehog (Hh) pathway, with potential antineoplastic activity. Upon administration, smoothened antagonist IPI-609 targets, binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations.

**Synonyms:** - IPI 269609 - IPI 609 - IPI-269609 - IPI-269609 - IPI-609 - IPI269609 - IPI609