Tinzaparin Sodium

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The sodium salt of a low molecular weight heparin (LMWH), obtained by controlled enzymatic depolymerization of heparin from porcine intestinal mucosa, with antithrombotic properties. Tinzaparin is a potent inhibitor of several activated coagulation factors, especially Factors Xa and IIa (thrombin); its primary activity is mediated through the plasma protease inhibitor antithrombin. In addition, this agent may inhibit angiogenesis through: 1) competitive binding of the heparin-binding sites on endothelial cells for the proangiogenic cytokines vascular endothelial growth factor (VEGF) and beta-fibroblast growth factor (beta-FGF) and 2) increasing the release of tissue factor pathway inhibitor (TFPI), a negative regulator of angiogenesis.

**Synonyms:** - Enzyme Depolymerized Heparin (MW 6500) - Inno-hep - Innohep - Innohep - LNH-1 - Logiparin - TINZAPARIN SODIUM - Tinzaparin - Tinzaparin Sodium Injection - tinzaparin sodium