Nedaplatin

**Semantic type:** Inorganic Chemical|Pharmacologic Substance

**Definition:** A second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.

**Synonyms:** - (Glycolato-O,O')diammineplatinum(II) - 254-S - CDGP - NDP - NEDAPLATIN - cis-Diammine(glucolato)platinum