LMNA wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LMNA wild-type allele is located within 1q22 and is approximately 25 kb in length. This allele, which encodes prelamin-A/C protein, plays a role in nuclear stability and chromatin structure. Mutations in the LMNA gene are associated with Charcot-Marie-Tooth disease, type 2B1, Hutchinson-Gilford progeria syndrome, Emery-Dreifuss muscular dystrophy, Malouf syndrome, autosomal dominant familial partial lipodystrophy type 2, lethal restrictive dermopathy, autosomal dominant limb girdle muscular dystrophy 1B and autosomal dominant dilated cardiomyopathy 1A..

**Synonyms:** - CDCD1 - CDDC - CMD1A - CMT2B1 - Cardiomyopathy, Dilated 1A (Autosomal Dominant) - EMD2 - FPL - FPLD - FPLD2 - HGPS - IDC - LDP1 - LFP - LGMD1B - LMN1 - LMNC - LMNL1 - Lamin A/C wt Allele - Lamin A/C-Like 1 Gene - Lamin-A/C Gene - Limb Girdle Muscular Dystrophy 1B (Autosomal Dominant) Gene - MADA - Mandibuloacral Dysplasia Type A Gene - PRO1 - Progeria 1 (Hutchinson-Gilford Type) Gene