Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7

**Semantic type:** Neoplastic Process

**Definition:** Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Supraglottis: Moderately advanced local disease. Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). Glottis: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus). Subglottis: Moderately advanced local disease. Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus). N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)

**Synonyms:** - Stage IVA Epidermoid Carcinoma of Larynx - Stage IVA Epidermoid Carcinoma of the Larynx - Stage IVA Laryngeal Epidermoid Carcinoma - Stage IVA Laryngeal Squamous Cell Carcinoma - Stage IVA Laryngeal Throat Squamous Cell Cancer - Stage IVA Larynx Epidermoid Carcinoma - Stage IVA Larynx Squamous Cell Carcinoma - Stage IVA Squamous Cell Carcinoma of Larynx - Stage IVA Squamous Cell Carcinoma of the Larynx