Paroxysmal Nocturnal Hemoglobinuria

**Semantic type:** Disease or Syndrome

**Definition:** A rare acquired hematologic disorder characterized by hemolytic anemia, dark-colored urine due to the release of hemoglobin in the blood, and thrombosis. The episodes of hemolysis tend to occur at night. It is caused by a somatic mutation in the glycosylphosphatidylinositol biosynthesis gene.

**Synonyms:** - PNH - PNH - Paroxysmal Hemoglobinuria - paroxysmal nocturnal hemoglobinuria