Oportuzumab Monatox

**Semantic type:** Pharmacologic Substance

**Definition:** A fusion protein immunotoxin consisting of a humanized, single-chain monoclonal antibody fragment specific for the epithelial cell adhesion molecule (EpCAM) conjugated with a truncated form of Pseudomonas exotoxin A with potential antineoplastic activity. Oportuzumab monatox binds to Ep-CAM-positive tumor cells, thereby delivering the Pseudomonas exotoxin A moiety specifically; the Pseudomonas exotoxin A moiety then inactivates elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein synthesis in target cells. EpCAM, a cell surface protein, is expressed by a variety of tumor cells and is frequently found in head and neck cancers.

**Synonyms:** - OPORTUZUMAB MONATOX - Proxinium - Proxinium - VB4 845 - VB4-845 - VB4-845 - Vicinium - anti-EpCAM-Pseudomonas-exotoxin fusion protein