B-Raf/VEGFR-2 Inhibitor RAF265

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable small molecule with potential antineoplastic activity. CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms.

**Synonyms:** - CHIR-265 - CHIR-265 - RAF 265 - RAF-265 - RAF-265 - RAF265