Padoporfin

**Semantic type:** Pharmacologic Substance

**Definition:** A novel palladium-substituted bacteriochlorophyll derivative and photosensitizer with potential antitumor activity. Upon administration, inactive padoporfin is activated locally when the tumor bed is exposed to photoirradiation; the activated form induces local cytotoxic processes, resulting in local tissue damage, disruption of tumor vasculature, and tumor hypoxia and necrosis.

**Synonyms:** - (Hydrogen 3-((2(sup 2)R,7R,8R,17S,18S)-12-acetyl-7-ethyl-2(sup 2)-(methoxycarbonyl)-3,8,13,17-tetramethyl-2(sup 1)-oxo-2(sup 1),2(sup 2),7,8,17,18-hexahydrocyclopenta(at)porphyrin-18-yl)propanoato-kappa4N(sup 21),N(sup 22),N(sup 23),N(sup 24))palladium - PADOPORFIN - Tookad - WST09