Cantuzumab Ravtansine

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** An immunotoxin of a humanized monoclonal antibody C242 (MoAb HuC242) conjugated to a derivative of the cytotoxic agent maytansine, DM4, with potential antitumor activity. Cantuzumab ravtansine is generated from MoAb C242, which is raised against a cell surface superantigen, CA242, found in a variety of human tumor cells. Upon binding and entry, the immunoconjugate releases the maytansinoid agent DM4, which binds to tubulin, thereby affecting microtubule assembly/disassembly dynamics. As a result, this agent prevents cell division and reduces cell growth of cancer cells that express CA242.

**Synonyms:** - CANTUZUMAB RAVTANSINE - HuC242-DM4 - IMGN242 - Maytansinoid DM4-Conjugated Humanized Monoclonal Antibody huC242 - huC242-DM4 - maytansinoid DM4-conjugated humanized monoclonal antibody huC242