Limonene, (+/-)-

**Semantic type:** Pharmacologic Substance

**Definition:** A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes.

**Synonyms:** - (+/-)-1-methyl-4-(1-methylethenyl)cyclohexene - 1-methyl-4-(1-methylethenyl)cyclohexene - 1-methyl-4-prop-1-en-2-yl-cyclohexene - Cajeputene - Cinene - DL-Limonene - Dipentene - Eulimen - LIMONENE, (+/-)- - Limonene - Nesol