Imipramine Pamoate

**Semantic type:** Pharmacologic Substance

**Definition:** The pamoate salt of imipramine, a synthetic dibenzazepine derivative with anti-depressant activity. Imipramine pamoate, a tricyclic antidepressant (TCA) potentiates the activity of adrenergic synapses by blocking the re-uptake of norepinephrine and serotonin, thereby preventing their degradation and increasing their availability. This drug also has antimuscarinic and anti-histamine properties, which contribute to its side effects.

**Synonyms:** - IMIPRAMINE PAMOATE - Tofranil-PM