Phentermine

**Semantic type:** Pharmacologic Substance

**Definition:** A natural monoamine alkaloid derivative and a sympathomimetic stimulant with appetite suppressant property. Phentermine, which was part of the Fen-Phen anti-obesity medication, stimulates hypothalamic release of norepinephrine, a neurotransmitter involved in stress responses (fight-or-flight reactions), and reduces hunger sensation. Phentermine also causes the release of epinephrine or adrenaline outside of the brain, resulting in breakdown of stored fat.

**Synonyms:** - 1,1-Dimethyl-2-phenylethylamine - 2-Amino-2-methyl-1-phenylpropane - 2-Phenyl-tert-butylamine - PHENTERMINE