Proparacaine

**Semantic type:** Pharmacologic Substance

**Definition:** A benzoic acid derivative anesthetic agent, with local anesthetic activity. Upon administration, proparacaine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels. This inhibits the sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, increases the threshold for electrical stimulation and results in a loss of sensation.

**Synonyms:** - 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate - 3-Amino-4-propoxybenzoic acid 2-(diethylamino)ethyl Ester - PROPARACAINE - Proxymetacaine