Sorafenib

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.

**Synonyms:** - BA4 43 9006 - BAY 43 9006 - BAY 43-9006 - BAY 43-9006 - BAY 439006 - BAY-43-9006 - BAY439006 - Bay-439006 - SORAFENIB - sorafenib