Tiotropium Bromide Monohydrate

**Semantic type:** Pharmacologic Substance

**Definition:** The monohydrate bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a long-acting muscarinic receptor antagonist, with bronchodilating activity. Upon inhalation, tiotropium binds to and blocks mainly muscarinic M3 receptors located on smooth muscle cells, thereby preventing smooth muscle contraction.

**Synonyms:** - 1,4-Dihydro-3,5-Diiodo-1-Methyl-4-Oxopyridine-2,6-Dicarboxylic Acid - 6Beta,7Beta-Epoxy-3Beta-Hydroxy-8-Methyl-1Alpha-H,5Alpha-H-Tropanium Bromide, Di-2-Thienylglycolate Monohydrate - Spiriva - TIOTROPIUM BROMIDE MONOHYDRATE