Flecainide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic agent derived from trifluoroethoxy-benzamide exhibiting antiarrhythmic and local anesthetic activity. As a class Ic antiarrhythmic that blocks sodium channels, flecainide depresses polarization phase 0 and decreases the induction velocity of the His-Purkinje system. It also decreases phase 4 slope and increases the depolarization threshold. (NCI04)

**Synonyms:** - FLECAINIDE - flecainide