Eltrombopag Olamine

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** The orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production.

**Synonyms:** - ELTROMBOPAG OLAMINE - Promacta - Promacta - SB 497115 GR - SB-497115-GR - SB497115GR - eltrombopag olamine