Fluorine F 18-fluoroazomycin Arabinoside

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A radiofluorinated 2-nitroimidazole derivative with positron-emitting radioisotope activity. Upon administration, fluorine F 18-fluoroazomycin arabinoside is reduced under hypoxic conditions in the tumor microenvironment to a reactive species that covalently binds to intracellular macromolecules, providing a quantitative measure of viable hypoxic tissue when imaged with positron emission tomography. Compared to 18F-misonidazole, fluorine F 18-fluoroazomycin arabinoside has a lower octanol:water partition coefficient; it therefore has less tendency to accumulate in lipophilic tissues and exhibits a faster renal clearance, which may result in improved imaging of hypoxic tissue.

**Synonyms:** - 18F-FAZA - 18F-Fluoroazomycin Arabinoside - 1H-Imidazole, 1-(5-Deoxy-5-(fluoro-18F)-alpha-D- - FAZA F-18 - FLUOROAZOMYCIN ARABINOSIDE F-18 - Fluoroazomycin Arabinoside F-18