18F-FHBG

**Semantic type:** Indicator, Reagent, or Diagnostic Aid|Organic Chemical|Pharmacologic Substance

**Definition:** A fluorine-18-labeled acycloguanosine derivative substrate for herpes simplex virus type-1 thymidine kinase (HSV1-tk). 18F-FHBG is used as a reporter probe to image the expression of the herpes simplex virus type-1 thymidine kinase (HSV1-tk) gene in gene transfer therapy. HSV1-tk and HSV1-tk-metabolized 18F-FHBG co-localize, allowing positron emission tomography (PET) localization of HSV1-tk gene-transfected tissue and the assessment of gene transfer efficiency.

**Synonyms:** - 9-(4-(18F)FLUORO-3-(HYDROXYMETHYL)BUTYL)GUANINE - 9-(4-18F-Fluoro-3-[hydroxymethyl]butyl)guanine - Reporter Probe 18F-FHBG