Tasisulam

**Semantic type:** Pharmacologic Substance

**Definition:** An acyl-sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). In combination with an angiogenesis inhibitor, this agent may exhibit synergistic antiangiogenic activity.

**Synonyms:** - LY-573636 - LY573636 - N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide - TASISULAM