Medroxyprogesterone

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. (NCI04)

**Synonyms:** - (6Alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione - 17Alpha-hydroxy-6alpha-methylprogesterone - 6Alpha-methyl-17alpha-hydroxyprogesterone - 6Alpha-methyl-4-pregnen-17alpha-ol-3,20-dione - Curretab - Curretab - MEDROXYPROGESTERONE - Medroxyprogesterone acetate - medroxyprogesterone