HyperCVAD Alternating with High-dose MTX AraC Regimen

**Semantic type:** Therapeutic or Preventive Procedure

**Definition:** A regimen consisting of cyclophosphamide, vincristine, doxorubicin and dexamethasone, administered on a hyperfractionated schedule, alternating with high-dose cytarabine and methotrexate, that can be used in the treatment of acute lymphoblastic leukemia (ALL) and certain types of non-Hodgkin lymphoma (NHL), including Burkitt lymphoma, HIV-related B-cell lymphoma, diffuse large B-cell lymphoma, and blastic plasmacytoid dendritic cell neoplasm (BPDCN).

**Synonyms:** - Cyclophosphamide/Vincristine/Doxorubicin/Dexamethasone Alternating with High-Dose Methotrexate/Cytarabine - Hyper-CVAD/MA - HyperCVAD Alternating with High Dose Methotrexate and Cytarabine - HyperCVAD Alternating with Methotrexate/Cytarabine - HyperCVAD-HD MTX AraC Regimen - HyperCVAD/HD MTX AraC Regimen - HyperCVAD/MTX-Ara-C - HyperCVAD/MTX/AraC - Hyperfractionated Cyclophosphamide-Vincristine-Adriamycin-Dexamethasone Alternating with Cytarabine/Methotrexate Regimen - Hyperfractionated Cyclophosphamide-Vincristine-Adriamycin-Dexamethasone/High-dose Methotrexate-Cytarabine Regimen