2-Hydroxyestrone

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A metabolite formed during the catabolism of estrone by the liver through the hydroxylation of the carbon at position 2 by cytochrome P450 (CYP) enzymes, including CYP1A1 and 1A2, with potential anticarcinogenic activity. The mechanism of action for the antitumor activity of 2-hydroxyestrone is not known but this metabolic product has minimal estrogenic activity compared to the parent compound and other estrone metabolites. Additionally, O-methylation of this compound produces 2-methoxyestradiol (2-MeOE2), which is a potent inhibitor of both cell proliferation and angiogenesis.

**Synonyms:** - 1,3,5(10)-Estratrien-2,3-diol-17-one - 2-HYDROXYESTRONE - 2-OHE(1) - 2-OHE1 - Catecholestrone - Estra-1,3,5(1)-Trien-17-One, 2,3-Dihydroxy-