Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** Human autologous peripheral blood lymphocytes (PBLs) transduced with an anti-p53 T cell receptor gene with potential antineoplastic activity. PBLs are harvested from a patient and pulsed with a retroviral vector that encodes the T-cell receptor gene specific for a mutated form of p53. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these modified PBLs express the anti-p53 T cell receptor which binds to mutant p53-overexpressing tumor cells; PBL-mediated tumor growth inhibition may follow. Many tumor cell types overexpress mutant p53 proteins, which are associated with the loss of apoptosis regulation and abnormal cell proliferation.

**Synonyms:** - Anti-p53 T-Cell Receptor Retroviral Vector-Transduced Peripheral Blood Lymphocytes - Anti-p53 TCR Retroviral Vector-Transduced PBL - Anti-p53 TCR-Transduced PBL