Cefotiam Hydrochloride

**Semantic type:** Antibiotic|Pharmacologic Substance

**Definition:** The hydrochloride salt form of cefotiam, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

**Synonyms:** - CEFOTIAM HYDROCHLORIDE