Demecarium Bromide

**Semantic type:** Pharmacologic Substance

**Definition:** The bromide salt form of demecarium, a quaternary ammonium compound and a long-acting cholinesterase inhibitor with parasympathomimetic activity. When used topically, demecarium inactivates both pseudocholinesterase and acetylcholinesterase, thereby preventing acetylcholine breakdown and increasing acetylcholine activity. This causes contraction of the iris sphincter muscle (producing miosis) and the ciliary muscle (affecting the accommodation reflex). In so doing, this agent increases the outflow of the aqueous humor, thereby reducing intraocular pressure.

**Synonyms:** - (m-Hydroxyphenyl)trimethylammonium Bromide Decamethylenebis(methylcarbamate) (2:1) - DEMECARIUM BROMIDE - Humorsol - Visumiotic