Eprodisate Disodium

**Semantic type:** Pharmacologic Substance

**Definition:** The orally available disodium salt form of eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis. Upon administration, eprodisate competitively binds to the glycosaminoglycan binding sites on serum amyloid A (SAA), which inhibits the formation of the glycosaminoglycan-amyloid fibril aggregate. This prevents the formation of amyloid deposits in certain organs, especially the kidneys, in AA amyloidosis.

**Synonyms:** - 1,3-Propanedisulfonic Acid, Disodium Salt - EPRODISATE DISODIUM - NC 503