Etilefrine Pivalate

**Semantic type:** Pharmacologic Substance

**Definition:** A prodrug of etilefrine, an adrenergic agonist with vasoconstrictive activity. Etilefrine pivalate is hydrolyzed to etilefrine, which binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to a decrease in venous pooling and increase in blood pressure. This agent may also stimulate beta-1 adrenergic receptors leading to positive chronotropic and inotropic effects.

**Synonyms:** - (+-)-m-((Ethylamino)-1-hydroxyethyl)phenyl Pivalate - ETILEFRINE PIVALATE - K 30 052