Plicamycin

**Semantic type:** Amino Acid, Peptide, or Protein|Antibiotic|Pharmacologic Substance

**Definition:** An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04)

**Synonyms:** - A-2371 - A-2371 - Aureolic acid - Aureolic acid - MTH - Mithracin - Mithracin - Mithracin - Mithracine - Mithramycin - PA-144 - PA-144 - PLICAMYCIN - mithramycin - plicamycin